[BIOMECH - Innocenti] Development of a 3D finite element model of lung parenchyma to analyze emphysema progression and to develop physical clinical 3D-printed phantom
Context of the project:
Pulmonary emphysema is an abnormal, permanent enlargement of the air spaces distal to the terminal bronchioles, accompanied by the destruction of alveolar walls in the absence of obvious fibrosis .
At BEAMS department, a validated 2D finite element model of the lung parenchyma, aimed to the estimation of the progression of pulmonary emphysema was developed (figure 1) .
The aim of the thesis will be to extend the current model, developing a 3D model and to analyse change in material properties and other clinical parameters.
The 3D results of such model could be also used, once 3D printed as clinical phantom for a preclinical analysis of the patient status and evolution.
 Stefano Diciotti, Alessandro Nobis, Stefano Ciulli, Nicholas Landini, Mario Mascalchi, Nicola Sverzellati, Bernardo Innocenti, 2016. Development of digital phantoms based on a finite element model to simulate low-attenuation areas in CT imaging for pulmonary emphysema quantification. Int J Comput Ass Rad, in press.